2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor.

  title={2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor.},
  author={Satomi Kagota and Yusuke Yamaguchi and Kazuki Nakamura and Takayuki Sugiura and Keizo Waku and Masaru Kunitomo},
  journal={European journal of pharmacology},
  volume={415 2-3},
We investigated whether 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, is involved in acetylcholine- and calcium ionophore A23187-induced relaxations in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME) and indomethacin, which is considered to be mediated by endothelium-derived hyperpolarizing factor (EDHF). In rabbit mesenteric arterial rings pre-constricted with noradrenaline, 2-arachidonoylglycerol caused concentration-dependent relaxation. The 2… CONTINUE READING
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