2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.

  title={2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.},
  author={Jinlong Jiang and Myle Hoang and Jonathan R Young and Danny Chaung and Ronsar Eid and Cherilyn Turner and Peter Yao-tang Lin and Xinchun Tong and J Wang and Carina P. Tan and Scott Feighner and Oksana C. Palyha and Donna L. Hreniuk and Jie Pan and Andreas W. Sailer and Douglas J. Macneil and Andrew Howard and Lauren Shearman and Sloan Stribling and Ramon E Camacho and Alison Strack and Lex H T van der Ploeg and Mark T. Goulet and Robert J DeVita},
  journal={Bioorganic & medicinal chemistry letters},
  volume={16 20},
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.