2-Aminofluorene bioactivation by human term placental peroxidase.

@article{Murthy19952AminofluoreneBB,
  title={2-Aminofluorene bioactivation by human term placental peroxidase.},
  author={K. Murthy and P. Joseph and A. Kulkarni},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={1995},
  volume={15 3},
  pages={
          115-26
        }
}
Earlier investigations from our laboratory demonstrated that human term placental peroxidase (HTPP) is capable of metabolism of xenobiotics and endogenous compounds. In this study, purified HTPP was found to bioactivate 2-aminofluorene (2-AF) in the presence of H2O2. 2-AF oxidation was studied spectrophotometrically while radiometry was employed to assess the bioactivation. The rate of oxidation and covalent binding to protein and DNA was dependent upon the pH of the reaction medium and the… Expand
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