2-Amino diphenylsulfides as new inhibitors of trypanothione reductase.

  title={2-Amino diphenylsulfides as new inhibitors of trypanothione reductase.},
  author={R Fernandez-Gomez and Mireille Moutiez and Marc Aumercier and G Bethegnies and Michel Luyckx and Ali Ouaissi and Andr{\'e} Tartar and Christian Sergheraert},
  journal={International journal of antimicrobial agents},
  volume={6 2},
Trypanothione reductase (TR) is the primary enzyme responsible for the reduction of trypanothione, the analog of glutathione found in trypanosomatidae. We have discovered a series of diphenylsulfides which are potent inhibitors of TR and have no activity on mammalian glutathione reductase. These compounds are also active in vitro on various stages of the parasite. Although structurally related to phenothiazines, which are known to be TR inhibitors, these compounds are devoided of any… CONTINUE READING