2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.

@article{Lambe19952Amino6methoxypurineAA,
  title={2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.},
  author={Catherine U Lambe and Devron R Averett and Melanie T. Paff and Judith E Reardon and Joan G. Wilson and Thomas A. Krenitsky},
  journal={Cancer research},
  year={1995},
  volume={55 15},
  pages={3352-6}
}
Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells. However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside (506U) is a water-soluble prodrug converted to ara-G by adenosine deaminase. 506U is not a substrate for deoxycytidine kinase, adenosine kinase, or purine nucleoside phosphorylase and is phosphorylated by mitochondrial deoxyguanosine kinase at a… CONTINUE READING