2-(3'-Hydroxypropylidene)-1alpha-hydroxy-19-norvitamin D compounds with truncated side chains.


Our recent studies with 2-(3'-hydroxypropylidene) analogs of 1alpha,25-dihydroxy-19-norvitamin D(3) showed that this 2-substituent creates compounds with very potent biological activity. In the continuing search for vitamin D compounds with selective activity profiles, we prepared a series of 1alpha-hydroxy-19-norvitamin D analogs characterized by the… (More)


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@article{Glebocka200723Hydroxypropylidene1alphahydroxy, title={2-(3'-Hydroxypropylidene)-1alpha-hydroxy-19-norvitamin D compounds with truncated side chains.}, author={Agnieszka Glebocka and Rafal R. Sicinski and Lori A. Plum and Hector F Deluca}, journal={The Journal of steroid biochemistry and molecular biology}, year={2007}, volume={103 3-5}, pages={310-5} }