2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype.

@article{Reichwald200823aryl3oxopropen1yl9tertbutylpau,
  title={2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype.},
  author={Christina Reichwald and Orly Shimony and Ute Dunkel and Nina Sacerdoti-Sierra and Charles L Jaffe and Conrad Kunick},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 3},
  pages={659-65}
}
A screening program directed to find new agents against Leishmania donovani, the parasite causing visceral leishmaniasis, revealed that paullones attenuate the proliferation of axenic amastigotes. Because these structures were not active in a test system involving infected macrophages, a structure optimization campaign was carried out. Concomitant… CONTINUE READING