• Corpus ID: 101969431

2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.

  title={2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells.},
  author={郭盛助 and 鍾景光 and 黃麗嬌},

Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.

Human liver cancer cells treated with chrysophanol exhibited a cellular pattern associated with necrosis and not apoptosis, and reductions in adenosine triphosphate levels and increases in lactate dehydrogenase activity indicated that chrysophile stimulated necrotic cell death.

Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.

Curcumin exerts its anticancer effects on lung cancer NCI-H460 cells through apoptosis or cell cycle arrest and down-regulation of cyclin-dependent kinase 1 (CDK1) is involved.

Capsaicin-induced apoptosis in human hepatoma HepG2 cells.

The results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

Results from mechanism of action studies revealed that these new quinolone derivatives function as antitubulin agents.

The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells.

It is demonstrated that rhein induces apoptosis in A-549 cells via a Ca2+ -dependent mitochondrial pathway.

Der p2 activates airway smooth muscle cells in a TLR2/MyD88‐dependent manner to induce an inflammatory response

It is demonstrated that Der p2 raised nuclear factor‐kappa B (NF‐κB) and extracellular signal‐regulated kinase (ERK) 1/2 activation and induced a high level of proinflammatory cytokines expression in primary cultured ASM cells, suggesting that Derp2 induces asthma through the MyD88 signaling pathway in respiratory tissue.

The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway.

Baicalein induced apoptosis in a time-dependent effect through the inhibition of Bcl-2 expression, increased the levels of Bax, reduced the level of deltapsim, and promoted the cytochrome c release and caspase-3 activation.