2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.

@article{Chen200921Hydroxethyl48dihydrobenzo12b54bdith,
  title={2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.},
  author={Chun-Jen Chen and Yen-Fang Wen and Pi Tsan Huang and Mei-Hua Hsu and Kuo Hsiung Lee and Mei-Hwai Chen and Wuu-Chian Shin and Li‐Jiau Huang and Sheng-Chu Kuo},
  journal={Leukemia research},
  year={2009},
  volume={33 12},
  pages={
          1664-9
        }
}
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) is a potent enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of BTP-11 and ATRA cut down the concentration of ATRA significantly, and that BTP-11 promoted the progression of ATRA-induced into the terminal granulocytic differentiation. Further, Western blot analysis revealed that combination of BTP-11 and ATRA decreased cyclin D/CDK4 and increased C/EBPvarepsilon protein… Expand
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Two ester-type hydrophilic prodrugs are identified in this paper as new anti-leukemic drug candidates and exhibited excellent and equally potent differentiation effects on HL-60 cells. Expand
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