2',4'-Dihydroxychalcone-induced apoptosis of human gastric cancer MGC-803 cells via down-regulation of survivin mRNA.

@article{Lou201024DihydroxychalconeinducedAO,
  title={2',4'-Dihydroxychalcone-induced apoptosis of human gastric cancer MGC-803 cells via down-regulation of survivin mRNA.},
  author={Chenghua Lou and Guangming Yang and Hao Cai and Mingchang Zou and Zisheng Xu and Yu Li and Fengming Zhao and Weidong Li and Li Tong and Mingyan Wang and Baochang Cai},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 5},
  pages={1333-7}
}
2',4'-Dihydroxychalcone (TFC), a main component in Herba Oxytropis, is grouped under flavonoids, which are well known to have antitumor activities in vitro. In this study, the possible antitumor mechanism of TFC in human gastric cancer MGC-803 cells is examined. Hoechst 33258 staining analysis indicates that TFC causes MGC-803 cell shrinkage and apoptotic body formation, typical characteristics of apoptosis. Flow cytometric analysis demonstrates that TFC causes cell cycle arrest in the G2/M… CONTINUE READING