2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

@inproceedings{Szretter20122OMO,
  title={2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo},
  author={Kristy J. Szretter and Brian P. Daniels and Hyelim Cho and Maria D Gainey and Wayne M Yokoyama and Michael Gale and Herbert W Virgin and Robyn S Klein and Ganes C Sen and Michael S Diamond},
  booktitle={PLoS pathogens},
  year={2012}
}
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exhibited attenuation in primary macrophages that was rescued in cells lacking Ifit1 gene expression. Here, we examined the role of Ifit1 in restricting pathogenesis in vivo of wild type WNV (WNV-WT) and a mutant in the NS5 gene (WNV-E218A) lacking 2… CONTINUE READING
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