2‐Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase

  title={2‐Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase},
  author={A. P. Green and A. J. Sweetman and M. Hooper},
  journal={Journal of Pharmacy and Pharmacology},
  • A. P. Green, A. J. Sweetman, M. Hooper
  • Published 1971
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
  • Previous investigations have shown that 2-phenylisatogen, a potentially useful anti-mycoplasma agent (Bond, 1969), inhibited ADP-stimulated succinate oxidation and uncoupler stimulated ATPase in tightly coupled rat liver mitochondria at a concentration of 12.5 nmol/ mg mitochondrial protein (Sweetman, Green & Hooper, 1971). We have proposed that the site of action of 2-phenylisatogen is similar to that of the antibiotics oligomycin and aurovertin, which have been shown to inhibit the… CONTINUE READING
    1 Citations

    Topics from this paper