2‐Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase

A. P. Green; A. J. Sweetman; M. Hooper

DOI:10.1111/j.2042-7158.1971.tb08839.x

Corpus ID: 41110008

2‐Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase

@article{Green19712PhenylisatogenAA,
  title={2‐Phenylisatogen as an electron acceptor for mitochondrial NADH dehydrogenase},
  author={A. P. Green and A. J. Sweetman and M. Hooper},
  journal={Journal of Pharmacy and Pharmacology},
  year={1971},
  volume={23}
}

A. P. Green, A. J. Sweetman, M. Hooper

Published 1971

Chemistry, Medicine

Journal of Pharmacy and Pharmacology

Previous investigations have shown that 2-phenylisatogen, a potentially useful anti-mycoplasma agent (Bond, 1969), inhibited ADP-stimulated succinate oxidation and uncoupler stimulated ATPase in tightly coupled rat liver mitochondria at a concentration of 12.5 nmol/ mg mitochondrial protein (Sweetman, Green & Hooper, 1971). We have proposed that the site of action of 2-phenylisatogen is similar to that of the antibiotics oligomycin and aurovertin, which have been shown to inhibit the… CONTINUE READING

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