2‐Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2+‐dependent and ‐independent mechanisms

@article{Kondo19982ArachidonoylglycerolAE,
  title={2‐Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2+‐dependent and ‐independent mechanisms},
  author={Sachiko Kondo and Hirobumi Kondo and Shinji Nakane and Tomoko Kodaka and Akira Tokumura and Keizo Waku and Takayuki Sugiura},
  journal={FEBS Letters},
  year={1998},
  volume={429}
}
The molecular species compositions of monoacylglycerols obtained from various rat tissues were examined by reverse‐phase high‐performance liquid chromatography (HPLC) and gas chromatography‐mass spectrometry (GC‐MS) analyses. We confirmed that 2‐arachidonoylglycerol, an endogenous cannabinoid receptor agonist, is one of the most abundant molecular species of monoacylglycerols in the brain. Substantial amounts of 2‐arachidonoylglycerol were also found in the liver, spleen, lung and kidney, but… Expand
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