2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: synthesis, biochemical and molecular modelling studies.

@article{Biagi200529disubstitutedN6arylcarbamoyl8azaad,
  title={2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: synthesis, biochemical and molecular modelling studies.},
  author={G. Biagi and A. Bianucci and A. Coi and B. Costa and L. Fabbrini and I. Giorgi and O. Livi and Iolanda Micco and F. Pacchini and Edoardo Santini and M. Leonardi and F. A. Nofal and O. L. Salerni and V. Scartoni},
  journal={Bioorganic \& medicinal chemistry},
  year={2005},
  volume={13 15},
  pages={
          4679-93
        }
}
A number of N6-(N-arylcarbamoyl)-2-substituted-9-benzyl-8-azaadenines, obtained by a modification of the synthetic scheme used to prepare selective A1 ligands, by only three or two steps, are described. At first we prepared a series of 2-phenyl-9-benzyl-8-azaadenines having as N6 substituent a variously substituted N-phenylcarbamoyl group. Some of these derivatives demonstrated good affinity towards the A3 subtype but low selectivity. Compounds having p-CF3, p-F and p-OCH3, as substituents on… Expand
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