2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.

  title={2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.},
  author={Lisa C W Chang and Ronald F Spanjersberg and Jacobien K. von Frijtag Drabbe K{\"u}nzel and Thea Mulder-Krieger and Johannes Brussee and Adriaan P. IJzerman},
  journal={Journal of medicinal chemistry},
  volume={49 10},
Purines have long been exploited as adenosine receptor antagonists. The substitution pattern about the purine ring has been well investigated, and certain criteria have become almost a prerequisite for good affinity at the adenosine A(1) receptor. The adaptation of the pharmacophore and the initial series of pyrimidines developed in an earlier publication resulted in a series of purines with an entirely new substitution pattern. One compound in particular, 8-cyclopentyl-2,6-diphenylpurine (31… 
38 Citations
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