2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug

@article{Snyder196725Dimethoxy4methylamphetamineA,
  title={2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug},
  author={Solomon H. Snyder and Louis A. Faillace and Leo E. Hollister},
  journal={Science},
  year={1967},
  volume={158},
  pages={669 - 670}
}
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically… 
View on AAAS
ncbi.nlm.nih.gov
136 Citations
Background Citations
10

136 Citations

Electroencephalographic Alerting Sites of d-Amphetamine and 2,5-Dimethoxy-4-methyl-amphetamine
TLDR
An electroencephalographic analysis is made to determine the sites of action in rabbit brain of d-amphetamine and STP to show that non-psychotomimetic congeners provoke EEG alerting from the midbrain level, while their psychotomimetics congeners cause alerting by their action at a lower level in the brain-stem.
DOET (2,5-dimethoxy-4-ethylamphetamine), a new psychotropic drug. Effects of varying doses in man.
TLDR
Over a five-fold range of pharmacologically active dosage, the "enhanced awareness" produced by DOET was not associated with psychotomimetic or hallucinogenic actions.
Some effects of the hallucinogenic drug 2,5-dimethoxy-4-methyl amphetamine on the metabolism of biogenic amines in the rat brain
  • B. Leonard
  • Biology, Chemistry
    Psychopharmacologia
  • 2004
TLDR
It was found that DOM increased the rate of incorporation of tyrosine into noradrenaline but reduced the incorporation of tryptophan into 5-hydroxytryptamine, which is shared by other hallucinogenic substances but not by the stimulant amphetamines.
The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus
TLDR
The present data suggest that those effects of mescaline in the rat which function as a discriminative stimulus are better correlated with pre-hallucinogenic LSD-like activity in man then with hallucinogenic activity per se.
An hallucinogenic amphetamine analog (DOM) in man
TLDR
The amphetamine analog, 2,5-dimethoxy-4-methylamphetamine (DOM), was studied in 18 volunteer subjects given single doses ranging from 2 to 14 mg, with definite psychotomimetic effects being evident from doses over 5 mg.
Some effects of the hallucinogenic drug 2,5-dimethoxy-4-methylamphetamine on the metabolism of biogenic amines in the rat brain.
  • B. Leonard
  • Medicine, Psychology
    British journal of pharmacology
  • 1972
TLDR
The results demonstrate that chronic ingestion of high doses of nicotine in drinking water can induce behavioural depression after doses of ethanol which do not have this effect when given alone and indicates that chronic nicotine may influence learning or memory processes.
Comparative effects of stereoisomers of psychotomimetic phenylisopropylamines.
Stereospecific actions of DOET (2,5-dimethoxy-4-ethylamphetamine) in man.
TLDR
A comparison of the psychotropic effects of isomers of DOET (2,5-dimethoxy-4-ethylamphetamine) a "psychedelic" methoxyamphetamine, in normal human subjects is reported, indicating the psychoactive conformation of the drug.
Relative potency of amphetamine derivatives and N,N-dimethyltryptamines
  • E. Uyeno
  • Chemistry, Biology
    Psychopharmacologia
  • 2004
TLDR
Dose-response curves showed that the increase in the latency was dose-dependent and the descending rank order of potency of the compounds, according to the median effective dose, was: DOET, psilocybin, DOM, DMT, 4-methoxy-DMT, and 6-hydroxy-D MT.
2,5-Dimethoxy-4-methylamphetamine (DOM)- a central component of its cardiovascular effects in rats; involvement of serotonin.
...
...

References

SHOWING 1-4 OF 4 REFERENCES
Up* is a mixture of Up and diHUp
    Brostoff was supported by a USPHS fellowship
      Sangavi, in preparation
      • Cliti. Pharniacol. Therap
      • 1964
      Supported by USPHS Grant AM-083090