2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug

@article{Snyder196725Dimethoxy4methylamphetamineA,
  title={2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug},
  author={Solomon H. Snyder and Louis A. Faillace and Leo E. Hollister},
  journal={Science},
  year={1967},
  volume={158},
  pages={669 - 670}
}
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically… 
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Electroencephalographic Alerting Sites of d-Amphetamine and 2,5-Dimethoxy-4-methyl-amphetamine
TLDR
An electroencephalographic analysis is made to determine the sites of action in rabbit brain of d-amphetamine and STP to show that non-psychotomimetic congeners provoke EEG alerting from the midbrain level, while their psychotomimetics congeners cause alerting by their action at a lower level in the brain-stem.
DOET (2,5-dimethoxy-4-ethylamphetamine), a new psychotropic drug. Effects of varying doses in man.
TLDR
Over a five-fold range of pharmacologically active dosage, the "enhanced awareness" produced by DOET was not associated with psychotomimetic or hallucinogenic actions.
Some effects of the hallucinogenic drug 2,5-dimethoxy-4-methyl amphetamine on the metabolism of biogenic amines in the rat brain
  • B. Leonard
  • Biology, Chemistry
    Psychopharmacologia
  • 2004
TLDR
It was found that DOM increased the rate of incorporation of tyrosine into noradrenaline but reduced the incorporation of tryptophan into 5-hydroxytryptamine, which is shared by other hallucinogenic substances but not by the stimulant amphetamines.
The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus
TLDR
The present data suggest that those effects of mescaline in the rat which function as a discriminative stimulus are better correlated with pre-hallucinogenic LSD-like activity in man then with hallucinogenic activity per se.
An hallucinogenic amphetamine analog (DOM) in man
TLDR
The amphetamine analog, 2,5-dimethoxy-4-methylamphetamine (DOM), was studied in 18 volunteer subjects given single doses ranging from 2 to 14 mg, with definite psychotomimetic effects being evident from doses over 5 mg.
Some effects of the hallucinogenic drug 2,5-dimethoxy-4-methylamphetamine on the metabolism of biogenic amines in the rat brain.
  • B. Leonard
  • Medicine, Psychology
    British journal of pharmacology
  • 1972
An analysis of variance indicated significant differences attributable to level of nicotine pre-treatment (P<0 01) and to ethanol dose (P<0 001). Comparisons of individual means showed that groups…
Comparative effects of stereoisomers of psychotomimetic phenylisopropylamines.
Stereospecific actions of DOET (2,5-dimethoxy-4-ethylamphetamine) in man.
TLDR
A comparison of the psychotropic effects of isomers of DOET (2,5-dimethoxy-4-ethylamphetamine) a "psychedelic" methoxyamphetamine, in normal human subjects is reported, indicating the psychoactive conformation of the drug.
Relative potency of amphetamine derivatives and N,N-dimethyltryptamines
  • E. Uyeno
  • Chemistry, Biology
    Psychopharmacologia
  • 2004
TLDR
Dose-response curves showed that the increase in the latency was dose-dependent and the descending rank order of potency of the compounds, according to the median effective dose, was: DOET, psilocybin, DOM, DMT, 4-methoxy-DMT, and 6-hydroxy-D MT.
2,5-Dimethoxy-4-methylamphetamine (DOM)- a central component of its cardiovascular effects in rats; involvement of serotonin.
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