2,5,2',5'-Tetrachlorobiphenyl impairs the bioenergetic functions of isolated rat liver mitochondria.

Abstract

The effects of 2,5,2',5'-tetrachlorobiphenyl (25TCB) on parameters related to the bioenergetic functions of isolated rat liver mitochondria were investigated. State 3 respiration was inhibited by 25TCB with both succinate and glutamate/malate as the respiratory substrates. The extent of inhibition with succinate was larger than that observed with glutamate… (More)

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