2,4-Dinitrofluorobenzene modifies cellular proteins and induces macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells.

@article{Kim200924DinitrofluorobenzeneMC,
  title={2,4-Dinitrofluorobenzene modifies cellular proteins and induces macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells.},
  author={Dongbum Kim and Young-jin Kim and Jae-Nam Seo and Jinho Kim and Younghee Lee and Cheung-Seog Park and Dae-Won Kim and Doo-sik Kim and H. -J. Kwon},
  journal={Immunological investigations},
  year={2009},
  volume={38 2},
  pages={132-52}
}
The skin sensitizer 2,4-dinitrofluorobenzene (DNFB) provokes delayed hypersensitivity responses as a result of topical application to the skin. Here, we demonstrate that DNFB modifies proteins in RAW 264.7 cells and skin tissues in NC/Nga mice; we also show the functional involvement of DNFB-induced modification of cellular proteins in the DNFB-induced macrophage inflammatory protein (MIP)-2 gene expression in RAW 264.7 cells. In addition, we demonstrate that DNFB strongly induces reactive… CONTINUE READING