The high intracellular level of glutathione is maintained, in part, by the important redox enzyme glutathione reductase. This report describes the properties of a new inhibitor of glutathione reductase, 2,4-dihydroxybenzylamine (2,4-DHBA). The inhibition of glutathione reductase by both 2,4-DHBA and 1,3-bischloroethyl-nitrosourea (BCNU) requires the… (More)
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