2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.

@article{Chang2004246trisubstitutedPA,
  title={2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.},
  author={Lisa C W Chang and Ronald F Spanjersberg and Jacobien K. von Frijtag Drabbe K{\"u}nzel and Thea Mulder-Krieger and Gijs van den Hout and Margot W. Beukers and Johannes Brussee and Adriaan P. IJzerman},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 26},
  pages={
          6529-40
        }
}
Adenosine receptor antagonists usually possess a bi- or tricyclic heteroaromatic structure at their core with varying substitution patterns to achieve selectivity and/or greater affinity. Taking into account molecular modeling results from a series of potent adenosine A1 receptor antagonists, a pharmacophore was derived from which we show that a monocyclic core can be equally effective. To achieve a compound that may act at the CNS we propose imposing a restriction related to its polar surface… 
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