2,3-Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning.

@article{Graziano197823DimercaptosuccinicAA,
  title={2,3-Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning.},
  author={Joseph H. Graziano and J. K. L. Leong and Ernst Friedheim},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1978},
  volume={206 3},
  pages={696-700}
}
Using minimally lead-poisoned rats, we have measured urinary and fecal lead excretion in response to 2,3-dimercaptosuccinic acid (DMS) administered i.p. or p.o. and compared it to that induced by dimercaptopropanol (BAL) (i.p.), EDTA (i.p.), D-penicillamine (p.o. and i.p.) and the combination of BAL and EDTA (i.p.). At doses of 30 mg/kg, parenterally administered DMS was as effective as i.p. BAL and these two drugs were more effective than the other treatment groups. However, p.o. DMS was only… CONTINUE READING
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