2,3-Dihydro-1-benzofuran derivatives as a series of potent selective cannabinoid receptor 2 agonists: design, synthesis, and binding mode prediction through ligand-steered modeling.

@article{Diaz200923Dihydro1benzofuranDA,
  title={2,3-Dihydro-1-benzofuran derivatives as a series of potent selective cannabinoid receptor 2 agonists: design, synthesis, and binding mode prediction through ligand-steered modeling.},
  author={Philippe Diaz and Sharangdhar S. Phatak and Jijun Xu and Frank R Fronczek and Fanny Astruc-Diaz and Charles M. Thompson and Claudio N. Cavasotto and Mohamed Naguib},
  journal={ChemMedChem},
  year={2009},
  volume={4 10},
  pages={1615-29}
}
We recently discovered and reported a series of N-alkyl-isatin acylhydrazone derivatives that are potent cannabinoid receptor 2 (CB(2)) agonists. In an effort to improve the druglike properties of these compounds and to better understand and improve the treatment of neuropathic pain, we designed and synthesized a new series of 2,3-dihydro-1-benzofuran derivatives bearing an asymmetric carbon atom that behave as potent selective CB(2) agonists. We used a multidisciplinary medicinal chemistry… CONTINUE READING