2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

  title={2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites},
  author={O. Sorg and M. Zennegg and P. Schmid and R. Fedosyuk and J. Saurat},
  journal={The Lancet},
  • O. Sorg, M. Zennegg, +2 authors J. Saurat
  • Published 2009
  • Chemistry, Medicine
  • The Lancet
  • BACKGROUND 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a long half-life of 5-10 years in human beings as a result of its high lipophilicity, and little or no metabolism. [...] Key Method We identified TCDD and its metabolites, and monitored their levels for 3 years using gas chromatography and high-resolution mass spectrometry in samples of blood serum, adipose tissue, faeces, skin, urine, and sweat, after they were extracted and cleaned with different organic solvents. Expand Abstract
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