2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

@article{Sorg20092378tetrachlorodibenzopdioxinP,
  title={2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites},
  author={Olivier Sorg and Markus Zennegg and Peter Schmid and Raisa M. Fedosyuk and R Valikhnovskyi and O Gaide and V Kniazevych and Jean Hilaire Saurat},
  journal={The Lancet},
  year={2009},
  volume={374},
  pages={1179-1185}
}

Figures and Tables from this paper

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain

A reverse set of changes in the AHR protein and mRNA response to TCDD and feed restriction is demonstrated, suggesting that AHR might function also as a physiological regulator, possibly involved in the maintenance of energy balance.

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

Results suggest TCDD elicits changes that support hepatic lipid accumulation, macrophage migration, and the progression of hepatic steatosis to steatohepatitis.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

Results suggest that systemic alterations in enterohepatic circulation, as well as host and microbiota bile acid metabolism, favor bile acids accumulation that contributes to AhR-mediated hepatotoxicity.

A new method for identification of in vitro metabolites of 2,3,7,8-TCDD with rat liver microsomes by using liquid chromatography-mass spectrometry

Two hydroxylated metabolites of 2,3,7,8-TCDD and four trichloro-dihydroxydibenzo-p-dioxins were identified from the direct LC-MS and MS/MS analyses of the incubated samples.

2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity

Time course and dose–response analyses of mRNA abundance following TCDD insult indicate that eight genes are similarly regulated in livers of both strains of rat, suggesting that they are not central to the severe L–E-specific T CDD-induced toxicities.

2,3,7,8-Tetrachlorodibenzo-p-dioxin elicited decreases in cobalamin inhibits methylmalonyl-CoA mutase activity redirecting propionyl-CoA metabolism to the β–oxidation-like pathway resulting in hepatic accumulation of the toxic intermediate acrylyl-CoA

Results suggest MUT activity was impaired due to Cbl depletion by TCDD causing propionyl-CoA metabolism to be redirected to the alternate Cbl-independent β–oxidation-like pathway resulting in hepatic acrylyl- CoA accumulation.

Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans

The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations.

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin alters sebaceous gland cell differentiation in vitro

Evidence is provided that TCDD effects on human sebocytes are mediated through the AhR signalling pathway, which affects the differentiation of sebaceous gland cells probably by switching humanSebaceous into keratinocyte‐like differentiation.
...

References

SHOWING 1-10 OF 37 REFERENCES

Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients

Abstract. In spring 1998, two women were diagnosed with severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication. Over the following 3 years, TCDD levels were monitored under various attempts

Determination of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin in human feces to ascertain its relative metabolism in man.

Human feces samples from a self-dosing experiment were analyzed by gas chromatography/mass spectrometry (GC/MS) for [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (3H-2378-TCDD) to determine that 36-44% of

Structure elucidation of mammalian TCDD-metabolites.

Biotransformation products of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) excreted in dog and rat bile were isolated and examined by combined gas chromatography-mass spectrometry (GC-MS). In the dog,

Biological degradation of TCDD in rats

Tritiated TCDD is used to search for metabolites in the bile of rats and marked changes in lipophilicity and mobility in TLC of the excreted radioactivity are found, hinting at the formation of phenolic hydroxyl groups in the dioxin molecule.

The effect of pretreatment on the biliary excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 3,3',4,4'-tetrachlorobiphenyl in the rat.

Biliary excretion and hepatic concentrations of [14C]TCDF were significantly increased in the pretreated animals and results suggest an autoinduction of TCDF metabolism.

Hepatic Uptake and Metabolism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran

The results suggest that TCDF will be far more persistent in rats, and possibly humans, following exposure at low doses which do not significantly induce cytochrome P450 1A1 and/or 1A2.

Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in

Effects of age, sex, and pharmacologic agents on the biliary elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in F344 rats.

Biliary excretion of radioactivity in both male and female juvenile rats was similar to that of adult males; senescent male rats excreted less, and Pretreatment with PB, DEX, or ABT resulted in similar decrease in biliaryexcretion of TCDD-derived radioactivity as observed in senescentmale rats.

The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity.

Human risk assessment for PCDDs and PCDFs needs to consider species-, congener-, and dose-specific toxicokinetic data, as exposure to complex mixtures, including PCBs, has the potential to alter the toxicokinetics of individual compounds.

Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

The high correlation between adipose tissue and serum 2,3,7,8-TCDD levels in this study indicates that serum 1,2,4,5,6-tetrachlorodibenzo-p-dioxin body burden concentration is a valid measurement of 2,1,8,9- TCDD body burden concentrations.