2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3.

@article{PueblaOsorio20042378Tetrachlorodibenzopdioxin,
  title={2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3.},
  author={Nahum Puebla-Osorio and Kenneth S. Ramos and M. Hadi Falahatpisheh and Roger Smith and Luc Remi Berghman},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2004},
  volume={138 4},
  pages={
          461-8
        }
}
The halogenated aromatic hydrocarbon 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to induce immunotoxicity, but relatively little is known regarding its effects on B-lymphocytes, and on avian B-cells in particular. In this study, the avian bursal pre-B-cell line DT40 was exposed to TCDD ranging from 1 to 500 nM for 1 and 6 h. At 100 nM, TCDD caused a significant increase in the number of apoptotic cells, as assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling… CONTINUE READING
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