2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced reduction of adenosine deaminase activity in vivo and in vitro.

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant in several animal species. The purpose of this study was to determine if TCDD affected the activity of adenosine deaminase (ADA), a purine metabolizing enzyme that is vital to the proper functioning of the immune system. The effect of TCDD on ADA activity was studied in various tissues… (More)

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@article{Muralidhara19942378TetrachlorodibenzopdioxinR, title={2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced reduction of adenosine deaminase activity in vivo and in vitro.}, author={Muralidhara and Fumiko Matsumura and Angela C Blankenship}, journal={Journal of biochemical toxicology}, year={1994}, volume={9 5}, pages={249-59} }