2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.

@article{Sul20092378TCDDNI,
  title={2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.},
  author={Donggun Sul and Hyo-shin Kim and Eun-kyung Cho and Min Jeoung Lee and Hyun Sook Kim and Woon-Won Jung and Kwang Woo Hwang and S Park},
  journal={Toxicology},
  year={2009},
  volume={255 1-2},
  pages={65-71}
}
One of the most notorious environmental toxicants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), easily accumulates in the environment and most organisms, including humans, because of its high lipophilicity and resistance to degradation. TCDD exposure causes a variety of adverse health effects in humans including immunotoxicity, hepatotoxicity, neurotoxicity, and carcinogenesis. For the most part, studies regarding the adverse effects of TCDD on the central nervous system (CNS) have been limited… CONTINUE READING

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