2,2',4,4',5,5'-hexabromobiphenyl: its toxicokinetics, biotransformation and porphyrinogenic action in rats.

@article{Koss1994224455hexabromobiphenylIT,
  title={2,2',4,4',5,5'-hexabromobiphenyl: its toxicokinetics, biotransformation and porphyrinogenic action in rats.},
  author={G. Koss and T Weider and Sandra Seubert and Andreas Seubert},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1994},
  volume={32 7},
  pages={605-10}
}
The porphyrinogenic action of 2,2',4,4',5,5'-hexabromobiphenyl and its toxicokinetics were studied in female Wistar rats that were treated every other day for 6 wk with oral doses of 112 mg/kg body weight. Subsequently, the animals were kept for a further period of 22.5 months but without supply of the brominated biphenyl. 10.5 months after cessation of treatment the compound reached a maximum concentration in the adipose tissue followed by a gradual decline of its content. In the liver the… CONTINUE READING