2'-deoxyribonolactone lesion in DNA: refined solution structure determined by nuclear magnetic resonance and molecular modeling.

@article{Jourdan19992deoxyribonolactoneLI,
  title={2'-deoxyribonolactone lesion in DNA: refined solution structure determined by nuclear magnetic resonance and molecular modeling.},
  author={Muriel Jourdan and Jes{\'u}s Garc{\'i}a and Eric Defrancq and Mitsuharu Kotera and Jean Lhomme},
  journal={Biochemistry},
  year={1999},
  volume={38 13},
  pages={3985-95}
}
The solution conformation of the DNA duplex d(C1G2C3A4C5L6C7A8C9G10C11).d(G12C13G14T15G16T17G18T19G20C21G22 ) containing the 2'-deoxyribonolactone lesion (L6) in the middle of the sequence has been investigated by NMR spectroscopy and restrained molecular dynamics calculations. Interproton distances have been obtained by complete relaxation matrix analysis… CONTINUE READING