2'-Modified oligonucleotides for antisense therapeutics.

  title={2'-Modified oligonucleotides for antisense therapeutics.},
  author={Thazha P. Prakash and B. Venkatesh Bhat},
  journal={Current topics in medicinal chemistry},
  volume={7 7},
Chemically modified antisense oligonucleotides are currently progressing in multiple clinical trials. Among several chemical modifications made, modification of the 2'-position has proved most successful. Second generation antisense oligonucleotides incorporating these 2'-modifications exhibit high binding affinity to target RNA, enhanced metabolic stability, and improved pharmacokinetic and toxicity profiles. This is, in part, due to the enhanced biophysical properties of second generation… CONTINUE READING
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