2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase.

@article{Boyle200523dideoxynucleoside5G,
  title={2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase.},
  author={Nicholas A Boyle and Patrick Fagan and Jennifer L. Brooks and Marija Prhavc and John W. Lambert and P. Dan Cook},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2005},
  volume={24 10-12},
  pages={1651-64}
}
Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs which require three intracellular phosphorylation steps to yield their corresponding, biologically active, nucleoside triphosphate. In order to circumvent this often inefficient phosphorylation cascade, a plausible approach is to provide the active species directly in the form of a stabilized nucleoside triphosphate mimic. We have previously shown that such a mimic, namely 5'-alpha-Rp-borano-beta,gamma-(difluoromethylene… CONTINUE READING