1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

@article{Mackintosh20121qGA,
  title={1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma},
  author={Carlos Mackintosh and Jos{\'e} Luis Ord{\'o}{\~n}ez and Daniel Jose Garc{\'i}a-Dom{\'i}nguez and Vicky Sevillano and Antonio Llombart-Bosch and K{\'a}roly Szuhai and Katia Scotlandi and Marco Alberghini and Rafa{\"e}l Sciot and Friedl Sinnaeve and Pancras Cornelis Wilhelmus Hogendoorn and Piero Picci and Sakari Knuutila and Uta Dirksen and Maria Debiec-Rychter and K-l Schaefer and Enrique de {\'A}lava},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={1287-1298}
}
Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite carrying a poor prognosis, are infrequent. In this scenario identifying secondary genetic alterations with a significant prevalence could contribute to understand the molecular… CONTINUE READING