1p/19q loss within oligodendroglioma is predictive for response to first line temozolomide but not to salvage treatment.

@article{Kouwenhoven20061p19qLW,
  title={1p/19q loss within oligodendroglioma is predictive for response to first line temozolomide but not to salvage treatment.},
  author={Mathilde C. M. Kouwenhoven and Johan M. Kros and Pim J. French and Elize M Biemond-ter Stege and Wilfried J. Graveland and Martin J. B. Taphoorn and Alba A Brandes and Martin J. van den Bent},
  journal={European journal of cancer},
  year={2006},
  volume={42 15},
  pages={2499-503}
}
BACKGROUND Combined loss of 1p/19q predicts an almost 100% response rate to first line procarbazine, CCNU and vincristine chemotherapy (PCV) chemotherapy in oligodendroglial tumours. We assessed the impact of 1p and 19q loss on the outcome to first line temozolomide (TMZ) chemotherapy and to second line PCV or TMZ in progressive oligodendroglial tumours. MATERIALS AND METHODS Tumour samples from patients included in two prospective EORTC studies on first line and second line TMZ chemotherapy… CONTINUE READING