1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression.

@article{Harant19971alpha25dihydroxyvitaminDA,
  title={1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression.},
  author={Hanna Harant and Peter Andrew and Gudimetla Satyanarayana Reddy and E Foglar and Ivan J. D. Lindley},
  journal={European journal of biochemistry},
  year={1997},
  volume={250 1},
  pages={63-71}
}
Regulation of interleukin-8 (IL-8) gene transcription occurs mainly through the sequences -94 to -71 of the 5'-flanking region of the IL-8 gene, involving the transcription factors nuclear factor for interleukin-6 (NF-IL-6) and nuclear factor kappaB (NF-kappaB). The human melanoma cell line A3 was derived from G-361 cells by stable transfection with an IL-8… CONTINUE READING