1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action.

  title={1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action.},
  author={Hang Shi and Anthony W. Norman and William H Okamura and Anindita Sen and Michael B Zemel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={15 14},
We reported recently that suppression of the renal 1alpha,25-dihyroxyvitamin D3 (1lpha,25-(OH)2-D3) production in aP2-agouti transgenic mice by increasing dietary calcium decreases adipocyte intracellular Ca2+ ([Ca2+]i), stimulates lipolysis, inhibits lipogenesis, and reduces adiposity. However, it was not clear whether this modulation of adipocyte metabolism by dietary calcium is a direct effect of inhibition of 1alpha,25-(OH)2-D3-induced [Ca2+]i. Accordingly, we have now evaluated the direct… CONTINUE READING