Corpus ID: 30245779

1alpha,25-Dihydroxyvitamin D3 modulates CD38 expression on human lymphocytes.

@article{Stoeckler19961alpha25DihydroxyvitaminDM,
  title={1alpha,25-Dihydroxyvitamin D3 modulates CD38 expression on human lymphocytes.},
  author={J. Stoeckler and H. A. Stoeckler and N. Kouttab and A. Maizel},
  journal={Journal of immunology},
  year={1996},
  volume={157 11},
  pages={
          4908-17
        }
}
B cells from chronically stimulated tonsils displayed high initial mean CD38 levels that declined during in vitro culture, despite ligation of CD40 and/or the Ag receptor in the presence of IL-4. Exposure to 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) restored the initial CD38 expression on these stimulated cells and up-regulated the Ag on stimulated CD38-/low cells. 1,25(OH)2D3 enhanced CD38 expression by four- to sixfold on CD8- and CD8+ peripheral blood T cells following PHA activation. The… Expand
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