1H magnetic resonance spectroscopy of nanomelic chicken cartilage: effect of aggrecan depletion on cartilage T2.

@article{Mosher20031HMR,
  title={1H magnetic resonance spectroscopy of nanomelic chicken cartilage: effect of aggrecan depletion on cartilage T2.},
  author={Timothy J. Mosher and Qiang Chen and Michael B. Smith},
  journal={Osteoarthritis and cartilage},
  year={2003},
  volume={11 10},
  pages={709-15}
}
OBJECTIVE To determine the effect of proteoglycan depletion on cartilage proton magnetic resonance (MR) spectroscopy T2 using nanomelic chicken cartilage, a genetic mutant that completely lacks aggrecan. DESIGN Proton MR spectroscopic T2 measurements of normal embryonic and nanomelic femoral epiphyseal cartilage were obtained using a 96-echo pulse sequence with inter-echo delay times increased logarithmically over the TE period of 60 micros to 1.7 s. The relative intensity and distribution of… CONTINUE READING