1H and 31P NMR measurement of cerebral lactate, high-energy phosphate levels, and pH in humans during voluntary hyperventilation: associated EEG, capnographic, and Doppler findings.

@article{Rijen19891HA3,
  title={1H and 31P NMR measurement of cerebral lactate, high-energy phosphate levels, and pH in humans during voluntary hyperventilation: associated EEG, capnographic, and Doppler findings.},
  author={Peter C. van Rijen and Peter R. Luyten and J W van der Sprenkel and V. Kraaier and Alexander C. van Huffelen and Cornelis A. F. Tulleken and Jan A den Hollander},
  journal={Magnetic resonance in medicine},
  year={1989},
  volume={10 2},
  pages={
          182-93
        }
}
In order to explore the sensitivity of spatially resolved 1H and 31P NMR spectroscopy on a whole-body NMR instrument, cerebral metabolic changes in human volunteers were measured during hyperventilation provocation. During hyperventilation the flow velocity in the middle cerebral artery decreased significantly and the EEG showed a marked increase in slow activity. 1H NMR spectra revealed an increase in cerebral lactate concentration. 31P NMR spectra showed no changes in ATP or PCr peak heights… CONTINUE READING

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