1H and 13C HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo 1H MRS study of human high grade gliomas.

@article{MartnezBisbal20041HA1,
  title={1H and 13C HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo 1H MRS study of human high grade gliomas.},
  author={M. Carmen Mart{\'i}nez-Bisbal and Luis Mart{\'i}-Bonmat{\'i} and Jose Piquer and Antonio Revert and Pilar Ferrer and Jos{\'e} Luis Ll{\'a}cer and Martial Piotto and Olivier Assemat and Bernardo Celda},
  journal={NMR in biomedicine},
  year={2004},
  volume={17 4},
  pages={191-205}
}
High-resolution magic angle spinning (HR-MAS) one- and two-dimensional 1H and 13C nuclear magnetic resonance (NMR) spectroscopy has been used to study intact glioblastoma (GBM) brain tumour tissue. The results were compared with in vitro chemical extract and in vivo spectra. The resolution of 1H one-dimensional, 1H TOCSY and 13C HSQC HR-MAS spectra is comparable to that obtained on perchloric extracts. 13C HSQC HR-MAS spectra have been particularly useful for the identification of 37 different… CONTINUE READING

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