1H-NMR studies of the interaction between a self-complementary deoxyoligonucleotide duplex and indolo[2,3-b]quinoxaline derivatives active against herpes virus.

@article{Patel19911HNMRSO,
  title={1H-NMR studies of the interaction between a self-complementary deoxyoligonucleotide duplex and indolo[2,3-b]quinoxaline derivatives active against herpes virus.},
  author={N. Patel and J. Bergman and A. Gr{\"a}slund},
  journal={European journal of biochemistry},
  year={1991},
  volume={197 3},
  pages={
          597-604
        }
}
  • N. Patel, J. Bergman, A. Gräslund
  • Published 1991
  • Chemistry, Medicine
  • European journal of biochemistry
  • 1H NMR has been used to study the interactions of ellipticine and the ellipticine analogues 2-3-dimethyl-6-(2-dimethylaminoethyl)6H-indolo-[2,3-b]quinoxaline and 6-(2-dimethylaminoethyl)6H-indolo-[2,3-b]quinoxaline with the self-complementary decadeoxyribonucleotide d(CGCGATCGCG)2. The Watson-Crick H-bonded imino proton resonances were studied. The drugs were shown to bind to the duplex by intercalation involving slow exchange kinetics for the imino proton resonances on the NMR time scale (500… CONTINUE READING
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