1H NMR solution structure of an active monomeric interleukin-8.

Abstract

The solution structure of a monomeric form of interleukin-8 (IL-8) has been solved using 1H NMR spectroscopy. The chemically synthesized nonnatural analog [IL-8 (4-72) L25 NH-->NCH3] has the same activity as that of native IL-8. Thirty structures were generated using the hybrid distance geometry and simulated annealing protocol using the program X-PLOR. The… (More)

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Cite this paper

@article{Rajarathnam19951HNS, title={1H NMR solution structure of an active monomeric interleukin-8.}, author={Krishna Rajarathnam and I Clark-lewis and Brian D. Sykes}, journal={Biochemistry}, year={1995}, volume={34 40}, pages={12983-90} }