1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.

Abstract

The binding properties of huperzine A (1) with Torpediniforms Nacline acetylcholinesterase (TnAChE) were investigated by (1)H NMR methods. The noselective, selective and double-selective spin-lattice relaxation rates were acquired in absent and present of TnAChE at a ratio [ligand]/[protein]=1:0.005. The selective relaxation rates shown protons of 1 had… (More)

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Cite this paper

@article{Li20041HNR, title={1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.}, author={Yiming Li and Qian Li and Manchi Sun and Guoqiang Song and Shanhao Jiang and Dayuan Zhu}, journal={Bioorganic & medicinal chemistry letters}, year={2004}, volume={14 6}, pages={1585-8} }