1H NMR investigations of the molecular nature of low-molecular-mass calcium ions in biofluids

@article{Silwood20011HNI,
  title={1H NMR investigations of the molecular nature of low-molecular-mass calcium ions in biofluids},
  author={Christopher J. L. Silwood and Martin Grootveld and Edward Lynch},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2001},
  volume={7},
  pages={46-57}
}
Abstract. High-resolution 1H NMR spectroscopy was employed to explore the complexation of Ca2+ by low-molecular-mass biomolecules in human saliva. The results acquired revealed that the organic acid anion (OAA) citrate acts as a powerful oxygen-donor chelator for salivary Ca2+, and accurate determination of its resonances' frequencies and spin-system pattern could be successfully utilized to determine its degree of saturation with this metal ion. Computer modelling studies demonstrated that the… CONTINUE READING

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