1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer

@article{Pearce20121HNA,
  title={1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer},
  author={John M. Pearce and Mary C. Mahoney and Jing-Huei Lee and W J Chu and Kim M. Cecil and Stephen M Strakowski and Richard A. Komoroski},
  journal={Magnetic Resonance Materials in Physics, Biology and Medicine},
  year={2012},
  volume={26},
  pages={337-343}
}
The relative amounts of choline (Cho), phosphocholine (PC), and glycerophosphocholine (GPC) may be sensitive indicators of breast cancer and the degree of malignancy. Here we implement some simple modifications to a previously developed 1H NMR analysis of fine-needle-aspirate (FNA) biopsies designed to yield sufficient spectral resolution of Cho, PC, and GPC for usable relative quantitation of these metabolites. FNA biopsies of eighteen breast lesions were examined using our modified procedure… CONTINUE READING