1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

  title={1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis},
  author={H{\'e}l{\`e}ne Blasco and Philippe Corcia and Caroline Moreau and S{\'e}gol{\`e}ne Veau and Cl{\'e}mentine Fournier and P Vourc'h and Patrick Emond and Paul H. Gordon and P-F Pradat and Julien Praline and David Devos and L. Nadal-Desbarats and C. R. Andres},
  booktitle={PloS one},
BACKGROUND Pathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient evaluation. The aim of this study was to analyze the CSF of patients with ALS by (1)H NMR (Nuclear Magnetic Resonance) spectroscopy in order to identify biomarkers in the early stages of the disease, and to evaluate the biochemical factors involved in ALS. METHODOLOGY CSF samples were collected from patients with ALS at the… CONTINUE READING
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