1H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease

@inproceedings{Kim20141HNM,
  title={1H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease},
  author={Ju-Ae Kim and Hyo-jung Choi and Yong-Kook Kwon and Do Hyun Ryu and T Chong-Suk KwoN and G. T. Gene Hwang},
  booktitle={PloS one},
  year={2014}
}
Chronic kidney disease (CKD) is characterized by the gradual loss of the kidney function to excrete wastes and fluids from the blood. (1)H NMR-based metabolomics was exploited to investigate the altered metabolic pattern in rats with CKD induced by surgical reduction of the renal mass (i.e., 5/6 nephrectomy (5/6 Nx)), particularly for identifying specific metabolic biomarkers associated with early of CKD. Plasma metabolite profiling was performed in CKD rats (at 4- or 8-weeks after 5/6 Nx… CONTINUE READING