1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.

@article{Lee20041HMRSIOR,
  title={1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification.},
  author={Michael C. Lee and Andrea Pirzkall and Tracy R Mcknight and Sarah J. Nelson},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2004},
  volume={19 4},
  pages={379-88}
}
PURPOSE To identify radiation-induced changes in healthy white-matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities. MATERIALS AND METHODS 1H-MRSI was performed on 10 patients with grade IV gliomas who were to undergo radiation therapy. Choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) ratios were studied as a function of dose and time. The impact of these spectral changes… CONTINUE READING
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