quantification of 18 metabolites in shaort-echo-time 1H-MRI spectra of the rat brain [J
- J Pfeuffer, I Tkac, profile Provencher SW et al Toward an in vivo neurochemical
- J Magn Reson 141:104–120 Multimed Tools Appl
Hydrogen proton magnetic resonance spectroscopy (1H-MRS) was widely used in the auxiliary diagnosis of clinical diseases. However, in the previous study on hippocampal metabolites, the relative ratio of magnetic resonance spectroscopic data common area blow the crest or crest height was used for semi-quantitative or relative quantitative analysis. Although it was convenient to observe the change trend for this method, it could not accurately reflect the specific changes of various metabolites concentrations. So it had a certain limitation. Based on Linear Combination of Model Spectra (LCmodel) processing technology this paper introduced the spectroscopic imaging technology into the analysis procedures. The absolute concentration of brain metabolites was quantitatively detected in the hippocampus of adolescent obese metabolic syndrome. The results showed that the levels of NAA, Cho and MI in bilateral hippocampuses of adolescent metabolic syndrome were significantly decreased, especially in right hippocampus. The application of LCmodel software brought great convenience to realize the absolute quantification of metabolites in vivo.