1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.

@article{Peet20071HMI,
  title={1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.},
  author={Andrew C Peet and Carmel McConville and Martin Wilson and Barry A. Levine and Michelle Reed and Sara A Dyer and Emma C Edwards and Mary C Strachan and Dominic J. McMullan and Timothy M Wilkes and Richard G. Grundy},
  journal={NMR in biomedicine},
  year={2007},
  volume={20 7},
  pages={692-700}
}
Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses. Numerous studies have sought to identify the associated genetic abnormalities in the tumour, resulting in the identification of useful prognostic markers. In particular, the presence of multiple copies of the MYCN oncogene (referred to as MYCN amplification) has been found to confer a poor prognosis. However, the molecular pathways… CONTINUE READING

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