1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

@inproceedings{Ingrassia20121BIREDE,
  title={1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310},
  author={Rosaria Ingrassia and Annamaria Lanzillotta and Ilenia Sarnico and Marina Benarese and Francesco Blasi and Laura Borgese and Fabjola Bilo and Laura E. Depero and Alberto Chiarugi and Pier Franco Spano and Marina Pizzi},
  booktitle={PloS one},
  year={2012}
}
The molecular mechanisms responsible for increasing iron and neurodegeneration in brain ischemia are an interesting area of research which could open new therapeutic approaches. Previous evidence has shown that activation of nuclear factor kappa B (NF-κB) through RelA acetylation on Lys310 is the prerequisite for p50/RelA-mediated apoptosis in cellular and animal models of brain ischemia. We hypothesized that the increase of iron through a NF-κB-regulated 1B isoform of the divalent metal… CONTINUE READING