192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats.

@article{Pappas1996192IL,
  title={192 IgG-saporin lesion of basal forebrain cholinergic neurons in neonatal rats.},
  author={Bruce A. Pappas and Christopher M Davidson and Teresa Fortin and S Nallathamby and G B Park and Erich Mohr and Ronald G. Wiley},
  journal={Brain research. Developmental brain research},
  year={1996},
  volume={96 1-2},
  pages={52-61}
}
Seven day old rats received bilateral intraventricular injections (200 ng) of the immunotoxin 192 IgG-saporin. When assayed in adulthood, these rats showed an 84% loss of hippocampal and a 52% loss of cortical choline acetyltransferase (ChAT) activity. ChAT was unaffected in the caudate. Cholinergic neurons immunoreactive (IR) for the low affinity neurotrophin receptor (P75NTR) were severely reduced throughout the basal forebrain nuclei. Cortical and hippocampal norepinephrine were increased… CONTINUE READING

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